Several string theorists such as Brian Greene or Leonard Susskind and cosmologists such as Alexander Vilenkin have written popular books about physics but as far as I know, Lisa Randall is the only popular writer among the "high-energy phenomenologists", i.e. the theoretical particle physicists who think about Nature from the viewpoint of phenomena that have been observed or that may be observed in a foreseeable future (mostly at the particle accelerators).
And we, the readers, have been especially fortunate because the book about physics from the viewpoint of phenomenologists wasn't written by a random phenomenologist but by one of the most prominent ones. In fact, Randall was identified as the most referred to particle physicist - among both women and men, just to be sure - in a recent 5-year period. She remains extremely active and influential.
Knocking on Heaven's Door has two basic goals. One of them is to introduce the reader to the cutting-edge research in particle physics which is dominated by the LHC experiment. Collisions of protons inside the 27-kilometer ring on the Swiss-French border have interrupted decades of theoretical dominance and relative experimental impotence (even though the book describes some smaller colliders or LHC predecessors, too). Randall who constantly interacts with the experimenters offers us an exciting story of the LHC collider from its conception to the first femtobarn of collisions.
We learn how it was built, what it is composed of, how it accelerates the particles nearly to the speed of light, how it observes the products of every collision (in the detectors such as CMS and ATLAS) and identifies the particles that are born in the collisions, and how the resulting huge amounts of data are being processed by computers and statistical techniques to learn something new. However, we also learn many things about the human factor: who are the people who work there, how they interact with each other, how they assure their colleagues that they're right, what they like to cook, how the Americans differ from the Europeans, and so on. I am not aware of a competing book written in plain English that could give you the feeling of being an LHC insider. And the book covers not only the colliders but also experiments trying to detect dark matter on Earth and many others.
But the book has another, grander goal which is nothing less than to clarify how scientists actually think. Philosophers would call these issues "gnoseology" or "epistemology" but the content of their thoughts would be less tangible. Instead, Randall talks about the actual strategies and issues that are important and misconceptions that the laymen often believe. One of the key methods to organize our knowledge is the concept of scale: different basic objects and "effective theories" describing their mutual interactions are being used for different sizes or, equivalently, different energies per particle. For a particle phenomenologist, and not only for her, the laws of physics resemble a giant onion. The laws relevant for longer scales may in principle be derived from those at shorter scales. But the former are independent of many details of the latter and it is often useful to think about them independently.
These initial chapters about scale are no random musings. They're the essential skeleton on which particle physics (phenomenology but not just phenomenology) organizes the insights from the experiments such as the LHC. A related question is what it means for our knowledge to expand. The book does a very good job in explaining that the theories we typically use are approximate and aware of their own limitations; on the other hand, it means that when new phenomena and better theories are found, the older theories are not completely eliminated.
Randall's book also talks about non-physicists (in many cases, famous people from all walks of life whom Randall has met or whom she knows very well), their way of looking at the physical phenomena, and what a physicist finds funny about this looking. One example is the relationship between science and religion: Randall, who is obviously an atheist, doesn't stay on the surface. She is not satisfied with claiming that "religious people are silly" which is what many other books do (with a great commercial success) but she also tries to find the core differences. One of the major lessons is that scientists are able to live and work with ignorance or uncertainty about a particular issue; in fact, they view it as a part of their knowledge (especially if they know rather accurately where their knowledge ends). This point is often misunderstood by other self-described atheists whose thinking is actually religious and dogmatic in character.
For another example, a chapter is dedicated to the LHC doomsday scenarios which assume (or attempt to "prove") that the collider will create a black hole or another lethal object that will devour our blue planet. The book explains several different levels of evidence we have to be sure that such a catastrophe won't happen.
I forgot to say that the book also covers theoretical models (which are the focus of her first book, Warped Passages) that are being tested by the LHC, including the models with supersymmetry and especially extra dimensions for which Randall (and Sundrum) became particularly famous. The Higgs boson gets its well-deserved chapter as well. Randall compares the phenomenological, bottom-up approach to physics with the top-down approach favored by string theorists.
To summarize, it is a book about some very exciting and specific experimental developments that are underway combined with all the infrastructure one needs to place these experiments into their proper place and to interpret them correctly. Highly recommended to everyone who doesn't want to lose touch with particle physics and any cutting-edge science as of 2011. Randall is a multi-dimensional personality and so is her book: but I am confident that most readers may find a lower-dimensional projection of the book that will enrich the way how they look at the world.