- Tapa blanda: 320 páginas
- Editor: Garland Publishing Inc (2 de julio de 1991)
- Idioma: Inglés
- ISBN-10: 0815302703
- ISBN-13: 978-0815302704
- Ver el Índice completo
Introduction to Protein Structure (Inglés) Tapa blanda – 2 jul 1991
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Introduction to Protein Structure gives an up-to-date account of the principles of protein structure, with examples of key proteins in their biological context generously illustrated in full colour to illuminate the structural principles described in the text.
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One small thing I encountered several times in the book was redundant sentences, as if the editors missed some things periodically. This is hardly worth mentioning, and did not detract from the overall usefulness of the book.
'Protein Structure' requires some background in organic chemistry and in the ideas of molecular genetics. For example, you should already be familiar with steric hindrance and with the idea of regulatory regions in DNA. Branden and Tooze reward the prepared reader with a well-considered series of discussions. These include enzyme action, photosynthesis, virus self-assembly, muscle fibers, DNA binding, and more. I had never seen an actual chain of chemical events that turn light into usable chemical energy. This book stepped through it (for a bacterium, at least) in just few paragraphs and drawings. But the whole book is like that - it sustains a remarkable density of information, always in a very readable style.
The text is laid out in a simple and appealing way, and is profusely illustrated. The illustration is one of this book's wonderful strengths. Almost all of the discussion is carried in diagrams as well as in words, and the authors freely use as many different diagrams as needed to make each idea understandable. The illustration style is simple and consistent; most drawings use one of three or four conventions for describing proteins. Almost all of the illustrations seem to be hand-drawn with colored pencil. Still, the corpus of illsutrations is among the most communicative I have seen in any book. Artists aspiring to illustrate science (or to communicate any idea) should read Tufte, then treat this book as a uniquely successful case study.
My only complaint about this book had to do with the quality of its printing. A few pages in my copy have bad register, colors are not consistent from page to page, and the one major photograph is weirdly over-sharpened. I must also admit that I do not need a deep knowledge of protein structure and function - I scanned the book quickly, and read only parts with care. The book repaid that effort richly, and I expect that it will reward more careful readers even more. I'm not a biochemist, but I strongly recommend 'Protein Structure' to anyone at all interested in the topic.
The book, which would be suitable for an advanced undergraduate, graduate course or for biologist wishing to delve more into structure, begins with basic amino acid properties. The secondary structure elements of alpha helix and beta sheet are next introduced, along with some of the conventions used to illustrate structure in publications. How these structural elements are formed to build motifs, and motifs in turn are built into complex structures is discussed. Protein folding and flexibility are discussed, and proteins that assist in the process (e.g., chaperones, GroEL-GroES, disulfide isomerases) are highlighted.
The next several chapters deal with DNA structure, DNA recognition by helix-turn-helix motifs, and eukaryotic transcription factors. The various transcription factor families are outlined, with emphasis on their interactions with DNA. Next, the subject of enzyme catalysis is covered, using serine proteases as exemplars. Membrane proteins, signal transduction proteins, fibrous proteins and immune system components all have individual chapters that emphasize structural features in the service of function. There is a chapter on spherical virus assembly and structure. Two general chapters close the book: one on structure prediction and protein engineering and design, and a final chapter on protein structure determination, which deals with X-ray crystallography and NMR methods and studies.